| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-10-24 |
| タイトル |
|
|
タイトル |
In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nishikawa, Hiroyoshi
Sato, Eiichi
Brions, Gabriel
Chen, Li-Mei
Matsuo, Mitsuyoshi
Nagata, Yasuhiro
Ritter, Gerd
Jäger, Elke
Nomura, Hideki
Kondo, Shigeto
Tawara, Isao
Kato, Takuma
Shiku, Hiroshi
Old, Lloyd J.
Galán, Jorge E.
Gnjatic, Sacha
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of established NY-ESO-1-expressing tumors. Intratu-moral inoculation of S. typhimurium-NY-ESO-1 to NY-ESO-1-negative tumors resulted in delivery of antigen in vivo and led to tumor regression in the presence of preexisting NY-ESO-1-spedific CD8+ T cells. Specific T cell responses against at least 2 unrelated tumor antigens not contained in the vaccine were observed, demonstrating epitope spreading. We propose that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development. |
| 書誌情報 |
The journal of clinical investigation
巻 116,
号 7,
p. 1946-1954,
発行日 2006-07-03
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0021-9738 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00695520 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1172/JCI28045 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
American Society for Clinical Investigation |
| 関係URI |
|
|
|
関連名称 |
http://www.jci.org/articles/view/JCI28045 |
| 関係URI |
|
|
|
関連名称 |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?pubmedid=16794737 |
| ノート |
|
|
値 |
出版者版電子ジャーナルあり |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
30A7841.pdf (1.5 MB)
