High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population

Baffour Tonto, Prince

doi:10.1111/irv.13053

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High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population

http://hdl.handle.net/10076/0002000037

名前 / ファイル	ライセンス	アクション
2022DM0330 (1.73MB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2023-08-31

タイトル

High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population

言語

eng

キーワード

言語

主題Scheme

Other

主題

anaphylaxis

キーワード

言語

主題Scheme

Other

主題

influenza vaccine

キーワード

言語

主題Scheme

Other

主題

specific IgE

キーワード

言語

主題Scheme

Other

主題

specific IgG4

キーワード

言語

主題Scheme

Other

主題

specific IgG4/IgE ratio

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

著者

Baffour Tonto, Prince

著者（ヨミ）

姓名

バッファートント, プリンス

言語

抄録

内容記述タイプ

Abstract

内容記述

Background
Anaphylaxis following influenza vaccination is a rare but serious problem. The underlying immune responses are not well understood. This study elucidated the IgE and IgG antibody responses in healthy children and adolescents following inactivated influenza vaccines (IIVs).
Methods
The efficacy and safety of quadrivalent IIV (QIV) and trivalent IIV (TIV) were compared in healthy subjects aged 0–18 years. Serum IIV-specific IgE, IgG, and IgG4 levels (sIgE, sIgG, and sIgG4) were measured with ImmunoCAP. Hemagglutination inhibition (HI) assay was performed for each influenza virus subtype. Sera from earlier patients who developed anaphylaxis to different IIVs were similarly tested.
Results
A total of 393 subjects were enrolled: 96 were 6 months−2 years old, 100 were 3–5 years old, 100 were 6–12 years old, and 97 were 13–18 years old. No anaphylaxis was observed. Generally, QIV and TIV induced similar antibody responses. IIV-sIgE levels rose significantly after vaccination in the 6 months–2 years old and 3–5 years old groups, did not change in the 6–12 years old group, and decreased in the 13–18 years old group. In contrast, the IIV-sIgG4/sIgE ratio increased significantly after vaccination in all age groups. Sensitized subjects had significantly higher HI titers and IIV-sIgG levels in the youngest age group and higher IIV-sIgG4 levels in all age groups compared with the non-sensitized. The IIV-sIgG4/sIgE ratio in five patients with anaphylaxis was significantly lower than in age-matched healthy subjects.
Conclusion
IIVs induce IgE sensitization in healthy children but also robust IgG4 responses that may protect them from anaphylaxis.

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内容記述

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本文/Department of Child Health and Development, Mie University Graduate School of Medicine, Tsu, Japan

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発行日 2023-03-24

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2023-08-31 02:38:38.185444

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High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population

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