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First, we showed that NF-kappaB decoy suppress the cell invasion and cell growth of breast cancer cell line at the bone metastatic site, by inhibiting the expression of VCM-1and ICAM-1. Second, we demonstrated the effect of hyperthermic treatment strategy with magnetic nano-particle. Third, Photodynamic therapy(PDT) using acridine orange is proved to be effective treatment not only for the sarcoma, but also for metastatic bone tumors. Actually we started clinical application of PDT for the bone metastases. Finally, we developed the radiofrequency ablation (RFA) combined with thermo-sensitive liposome-embedding doxorubicin in an effort to safe and effective RFA treatment for the metastatic spinal tumor. Further investigation is necessary.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "22591654", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_18": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_text_value": "Development of novel physicochemical and molecular biological therapy for the metastatic bone tumors"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "加藤, 公", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松峯, 昭彦", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村, 知樹", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "里中, 東彦", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "内田, 淳正", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19678", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "30K17172.pdf", "filesize": [{"value": "331.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 331700.0, "url": {"label": "30K17172.pdf", "url": "https://mie-u.repo.nii.ac.jp/record/8050/files/30K17172.pdf"}, "version_id": "6431c4e0-ca65-4872-9ae7-527c321ba628"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "骨転移", "subitem_subject_scheme": "Other"}, {"subitem_subject": "磁性体温熱療法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アクリジンオレンジ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ラジオ波焼灼術", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NFκB decoy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究", "subitem_title_language": "ja"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670337748"], "permalink_uri": "http://hdl.handle.net/10076/14285", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-12-18"}, "publish_date": "2014-12-18", "publish_status": "0", "recid": "8050", "relation": {}, "relation_version_is_last": true, "title": ["がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究"], "weko_shared_id": -1}