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  1. 30 大学院医学系研究科・医学部
  2. 30K 科研費報告書
  3. 2014年度

2光子励起顕微鏡を用いた大腸癌化及び癌、周囲間質応答の新規確証提示

http://hdl.handle.net/10076/14938
http://hdl.handle.net/10076/14938
fc90790d-899c-4b71-980f-ecd9f02c63fc
名前 / ファイル ライセンス アクション
30K17494.pdf 30K17494.pdf (227.1 kB)
Item type 報告書 / Research Paper(1)
公開日 2016-01-15
タイトル
言語 ja
タイトル 2光子励起顕微鏡を用いた大腸癌化及び癌、周囲間質応答の新規確証提示
言語
言語 jpn
キーワード
主題Scheme Other
主題 二光子レーザー顕微鏡
キーワード
主題Scheme Other
主題 癌幹細胞
キーワード
主題Scheme Other
主題 癌-間質反応
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_18ws
資源タイプ research report
著者 楠, 正人

× 楠, 正人

WEKO 19696

ja 楠, 正人

Search repository
井上, 靖浩

× 井上, 靖浩

WEKO 19697

ja 井上, 靖浩

Search repository
三木, 誓雄

× 三木, 誓雄

WEKO 19698

ja 三木, 誓雄

Search repository
問山, 裕二

× 問山, 裕二

WEKO 19699

ja 問山, 裕二

Search repository
著者別名 Kusunoki, Masato

× Kusunoki, Masato

WEKO 19700

en Kusunoki, Masato

Search repository
Inoue, Yasuhiro

× Inoue, Yasuhiro

WEKO 19701

en Inoue, Yasuhiro

Search repository
Miki, Chikao

× Miki, Chikao

WEKO 19702

en Miki, Chikao

Search repository
Toiyama, Yuji

× Toiyama, Yuji

WEKO 19703

en Toiyama, Yuji

Search repository
抄録
内容記述タイプ Abstract
内容記述 大腸癌幹細胞が発癌過程または浸潤及び転移過程で周囲間質と相互作用をしながら進展していく様を二光励起顕微鏡で生体内可視化すること試みた。大腸癌肝転移モデルの早期では、癌細胞と肝類洞内皮細胞との接着及び停止、癌細細胞に胞血小板が付着するtumor cell induced platelet aggregation、癌細胞と白血球との相互作用が観察できた。後期では癌細胞塊と周囲間質及び腫瘍血管が観察できた。RFP-HT29の5-FU抵抗性クローンは癌細胞の紡錘形変化と瀰漫性増殖への変化と周囲の著明な間質反応が確認できた。
抄録
内容記述タイプ Abstract
内容記述 We attempted to visualize in vivo dynamic interactions between cancer stem cells (CSCs) and their surrounding stromal cells during the process of carcinogenesis, tumor invasion and metastasis in colorectal cancer using two photon laser scanning microscopy (TPLSM). We hypothesized that residual cancer cells after chemoradiotherapy (CRT) may contain putative CSCs which show not only CRT-resistant property, but also epithelial-mesenchymal transition (EMT) phenotype. On liver metastasis model, dynamic tumor-host interactions including tumor-endothelial, tumor-platelet, and tumor-leukocyte interactions were observed in vivo real-time by TPLSM. Treatment resistant clones (made by repeated exposure of anti-cancer drug or irradiation) were inoculated into mice, and visualized their characteristics in vivo real-time using TPLSM. The small fraction of treatment resistant clones showed spindle shaped morphology. Their growth pattern was changed from localized growth to diffusely invasive growth.
内容記述
内容記述タイプ Other
内容記述 2009年度~2013年度科学研究費補助金(基盤研究(B))研究成果報告書
書誌情報
発行日 2014-05-29
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
その他のタイトル
In vivo characterization of carcinogenesis and cancer-host interaction in colorectal cancer using two photon laser scanning microscopy
出版者
出版者 三重大学
科研費番号
内容記述タイプ Other
内容記述 21390377
資源タイプ(三重大)
Kaken / 科研費報告書
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