{"_buckets": {"deposit": "f9134389-3411-4c1a-9224-bb3d18498f45"}, "_deposit": {"created_by": 15, "id": "8073", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "8073"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00008073", "sets": ["1692670376097"]}, "author_link": ["19812", "19811"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-05-22", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TOYODA, Hidemi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19812", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "１才半以降に発症する神経芽腫の予後は不良であり、新しい治療法の開発が望まれている。これまで我々は、in vitroとin vivoの実験により、ポリオウイルス（PV）は神経芽腫に対し強い抗腫瘍効果をもち、さらにPVにより神経芽腫が治癒したマウスには、神経芽腫に対する抗腫瘍免疫が誘導されることを証明してきた。これらの基礎実験を踏まえ、三重大学病院では再発・難治性神経芽腫の患者さんを対象に、PVによる神経芽腫の第１相臨床試験を開始し、現在まで２名の患者さんの治療を行った。", "subitem_description_type": "Abstract"}, {"subitem_description": "The prognosis of neuroblastoma patients is poor. Thus, to develop a novel treatment is necessary. Our previous studies show that poliovirus has strong anti-neuroblastoma effects both in vitro and in vivo, and anti-neuroblastoma immune response was induced in neuroblastoma cured mice. In accordance with these findings, we started phase 1 clinical trial for relapse and refractory neuroblastoma patients. We have treated two relapsed neuroblastoma patients so far.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "24591547", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_18": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_text_value": "novel treatment for neuroblastoma by live-attenuated poliovirus"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "豊田, 秀実", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19811", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "30K17878.pdf", "filesize": [{"value": "289.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 289400.0, "url": {"label": "30K17878.pdf", "url": "https://mie-u.repo.nii.ac.jp/record/8073/files/30K17878.pdf"}, "version_id": "b332ed7c-6c6a-4a5d-a911-ad2861a0a20b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "神経芽腫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ポリオウイルス", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究", "subitem_title_language": "ja"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670376097"], "permalink_uri": "http://hdl.handle.net/10076/15486", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-01-13"}, "publish_date": "2017-01-13", "publish_status": "0", "recid": "8073", "relation": {}, "relation_version_is_last": true, "title": ["弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究"], "weko_shared_id": -1}