WEKO3
アイテム
Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy
http://hdl.handle.net/10076/00016976
http://hdl.handle.net/10076/00016976ec1aba8e-c730-460f-9050-bb220e9d8ee9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2015DM033 (11.4 MB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-07-04 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | EUS-FNAB | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | hENT1 | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | chemoradiotherapy | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | gemcitabine | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | pancreatic ductal adenocarcinoma | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
山田, 玲子
× 山田, 玲子
|
|||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Objectives: To clarify whether pretreatment human equilibrative nucleoside transporter (hENTl) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT), and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. Methods: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in the 51 of 76 PDAC patients who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. Results: The concordance rate of hENT1 expressions was 89.2% (K=0.681). Median survival time (month) in the 51 whole patients and 37 with resection was significantly longer in hENT1 positive than in negative: 25.0 and 30.0 vs. 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than negative patients , whose prognosis was similar to those without resection. Conclusions: The assessment of hENT1 expression using EUS-FNAB samples prior to Gem-CRT provides important information on PDAC patients who can benefit from curative-intent resection . | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 本文 / Gastroenterology and Hepatology, Mie University Graduate School of Medicine | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 55p | |||||||||||
| 書誌情報 |
発行日 2016-03-25 |
|||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1097/MPA.0000000000000597 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 三重大学 | |||||||||||
| 出版者（ヨミ） | ||||||||||||
| 値 | ミエダイガク | |||||||||||
| 関係URI | ||||||||||||
| 関連名称 | http://journals.lww.com/pancreasjournal/Fulltext/2016/05000/Human_Equilibrative_Nucleoside_Transporter_1.19.aspx | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士(医学) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 14101 | |||||||||||
| 学位授与機関名 | 三重大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2016-03-25 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲医学第1770号 | |||||||||||
| ノート | ||||||||||||
| 値 | Pancreas, 45 (5), 2016, pp761-771, ISSN : 0885-3177 に掲載 | |||||||||||
| 資源タイプ（三重大） | ||||||||||||
| 値 | Doctoral Dissertation / 博士論文 | |||||||||||
