{"_buckets": {"deposit": "ded9b587-16d2-462f-a3ed-42788b25dd19"}, "_deposit": {"created_by": 15, "id": "12432", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "12432"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00012432", "sets": ["1692670416720"]}, "author_link": ["40536", "40537", "40538", "40533", "40534", "40535"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-05-24", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "HIRAYAMA, Masahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40536", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IWAMOTO, Shotaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40537", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TOYODA, Hidemi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40538", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "造血細胞移植後の予後を左右する慢性GVHDの治療法はいまだ確立されていない。我々は以前に慢性GVHDでは主に抗炎症性単球がIL-10を産生し、障害された標的臓器の修復に関与していることを証明した。マクロファージには炎症型M1タイプと抗炎症型のM2タイプが存在する。このM2マクロファージを用いてGVHDの新規治療法の開発を行った。マウス骨髄細胞よりGM-CSFおよびM-CSFのサイトカインで培養することでそれぞれM1およびM2の２種類のマクロファージの誘導を行った。マウスGVHDモデルにおいてM2マクロファージは致死的GVHDを抑制し、生存率向上させた。今後の臨床応用が期待される。 ", "subitem_description_type": "Abstract"}, {"subitem_description": "Treatment of chronic GVHD, which influences prognosis after hematopoietic cell transplantation, has not yet been established. We have previously demonstrated that anti-inflammatory monocytes produce IL-10 in chronic GVHD and are involved in the repair of damaged target organs. There are inflammatory M1 type and anti-inflammatory type M2 type in macrophages. Using this M2 macrophage, a novel treatment for GVHD has developed. Two types of macrophages M1 and M2 were induced by culturing them with cytokines of GM-CSF and M-CSF from mouse bone marrow cells. In murine GVHD model, M2 macrophages reduced lethal GVHD and improved survival rate. Future clinical application has been expected.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "26461443", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_31": {"attribute_name": "出版者（ヨミ）", "attribute_value_mlt": [{"subitem_text_value": "ミエダイガク"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "平山, 雅浩", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "40533", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩本, 彰太郎", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "40534", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "豊田, 秀実", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "40535", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-05-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2018RP0041.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "2018RP0041", "url": "https://mie-u.repo.nii.ac.jp/record/12432/files/2018RP0041.pdf"}, "version_id": "73b26203-b3ed-4ee7-ba39-6fffc9e87129"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "移植片対宿主病", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マクロファージ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "単球", "subitem_subject_scheme": "Other"}, {"subitem_subject": "造血細胞移植", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発", "subitem_title_language": "ja"}, {"subitem_title": "Development of novel treatment for GVHD following hematopoietic cell transplantation using M2 macrophage", "subitem_title_language": "en"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670416720"], "permalink_uri": "http://hdl.handle.net/10076/00018064", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-05-08"}, "publish_date": "2019-05-08", "publish_status": "0", "recid": "12432", "relation": {}, "relation_version_is_last": true, "title": ["M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発"], "weko_shared_id": -1}