{"_buckets": {"deposit": "13aa023e-df60-4b66-8d92-2ef9dc046169"}, "_deposit": {"created_by": 15, "id": "15266", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "15266"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00015266", "sets": ["1692670514969"]}, "author_link": ["50318", "50319", "50320", "50321", "50314", "50315", "50316", "50317"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-05-19", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "DOHI, KAORU", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50318", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Masaaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50319", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto, Ryuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50320", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katayama, Kan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50321", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Dahl食塩感受性高血圧ラットを低食塩群(n=10)、高食塩群(n=10)、高食塩＋ SGLT2阻害薬 (ipragliflozin）群（n=10）、高食塩＋ARB(losartan)群(n=10)、高食塩＋SGLT2阻害薬＋ARB(n=10)群に振り分けた。併用投与群でのみ食塩感受性が改善した。併用投与群では単独治療に比べ腎硬化スコアの有意な改善を示し、心筋肥大ならびに線維化も改善所見が得られた。AT1R, NHE3およびNKCC2の蛋白発現がSGLT2阻害薬単独投与では低下しない一方で、併用療法では両者とも有意に抑制され、AT1R発現抑制作用に関してはARB単独投与よりもさらに優れていた。", "subitem_description_type": "Abstract"}, {"subitem_description": " Dahl salt-sensitive (DSS) hypertensive rats were treated orally for 8-weekswith normal salt diet (0.3% NaCl), high salt diet (8% NaCl), high salt diet with SGLT2 inhibitor(ipragliflozin 0.04%), high salt diet with ARB (losartan 0.05%), or high salt diet with combination treatment. Only the combination treatment lower blood pressure and improved salt-sensitivity. The combination treatment significantly ameliorated glomerulosclerosis, and reduced cardiomyocyte hypertrophy and perivascular fibrosis. Angiotensin II type 1 receptor (AT1R) protein expression level in the kidney was remarkably suppressed in the combination treatment group compared to the other high salt diet groups. The protein expression level of Na+/H+ exchanger isoform 3 and Na+-K+-Cl- cotransporter 2 were significantly decreased with losartan alone and combination with ipragliflozin.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "18K08101", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者（ヨミ）", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50314", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ドヒ, カオル", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "50315", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "イトウ, マサアキ", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "50316", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "オカモト, リュウジ", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "50317", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "カタヤマ, カン", "nameLang": "ja-Kana"}]}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_31": {"attribute_name": "出版者（ヨミ）", "attribute_value_mlt": [{"subitem_text_value": "ミエダイガク"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "土肥, 薫", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "伊藤, 正明", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "岡本, 隆二", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "片山, 鑑", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2022RP0027.pdf", "filesize": [{"value": "726.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 726400.0, "url": {"label": "2022RP0027", "url": "https://mie-u.repo.nii.ac.jp/record/15266/files/2022RP0027.pdf"}, "version_id": "5156edb9-f18e-40e1-8ba0-e6786cc89cf9"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "循環器", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討", "subitem_title_language": "ja"}, {"subitem_title": "The effect of sodium-glucose co-transporter 2 inhibition on heart failure prevention in Dahl salt-sensitive rats.", "subitem_title_language": "en"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670514969"], "permalink_uri": "http://hdl.handle.net/10076/00020884", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-11-24"}, "publish_date": "2022-11-24", "publish_status": "0", "recid": "15266", "relation": {}, "relation_version_is_last": true, "title": ["食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討"], "weko_shared_id": -1}