{"_buckets": {"deposit": "f85275c0-4e23-426c-8526-294d47edc295"}, "_deposit": {"created_by": 15, "id": "8006", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "8006"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00008006", "sets": ["1692670315782"]}, "author_link": ["19449", "19448"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-05-24", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Toyoda, hidemi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19449", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "我々は今まで、ポリオウイルス（PV）の神経細胞に対する親和性に着目し、PVを神経芽腫の治療に応用しようと試みてきました。我々は、マウスを用いた研究でPVは神経芽腫細胞に対して強い抗腫瘍活性を持ち、マウスに移植した腫瘍が消失する事を報告してきました。さらに驚いたことに神経芽腫をPVで治療することで抗腫瘍免疫が誘導されることが示唆されました。以上の結果をふまえ、三重大学医学部附属病院では2010年から、再発神経芽腫の患者さんに弱毒PVの腫瘍内投与により治療する、第１相の臨床試験を開始しました。 ", "subitem_description_type": "Abstract"}, {"subitem_description": "In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus (PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In accordance with these findings, we started phase 1 clinical trial, novel treatment of neuroblastoma by live-attenuated poliovirus.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "21591359", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_18": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_text_value": "Novel treatment of neuroblastoma by live-attenuated poliovirus"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "豊田, 秀実", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19448", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "30K16821.pdf", "filesize": [{"value": "439.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 439900.0, "url": {"label": "30K16821.pdf", "url": "https://mie-u.repo.nii.ac.jp/record/8006/files/30K16821.pdf"}, "version_id": "a6b7cb28-57a2-47d6-ba5e-221ac708f962"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "神経芽腫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ポリオウイルス", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "ポリオウイルスを用いた神経芽腫の新しい治療法の研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ポリオウイルスを用いた神経芽腫の新しい治療法の研究", "subitem_title_language": "ja"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670315782"], "permalink_uri": "http://hdl.handle.net/10076/13726", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-03-10"}, "publish_date": "2014-03-10", "publish_status": "0", "recid": "8006", "relation": {}, "relation_version_is_last": true, "title": ["ポリオウイルスを用いた神経芽腫の新しい治療法の研究"], "weko_shared_id": -1}