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In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy
http://hdl.handle.net/10076/11796
http://hdl.handle.net/10076/11796d9c6d7ad-7652-4780-b909-2199ddc02d1e
名前 / ファイル | ライセンス | アクション |
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39A15352.pdf (4.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-12-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tanaka, Koji
× Tanaka, Koji× Morimoto, Yuhki× Toiyama, Yuji× Matsushita, Kohei× Kawamura, Mikio× Koike, Yuhki× Okugawa, Yoshinaga× Inoue, Yasuhiro× Uchida, Keiichi× Araki, Toshimitsu× Mizoguchi, Akira× Kusunoki, Masato |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In vivo real-time visualization of the process of angiogenesis in secondary tumors in the same living animals presents a major challenge in metastasis research.We developed a technique for intravital imaging of colorectal liver metastasis development in live mice using two-photon laser scanning microscopy (TPLSM). We also developed time-series TPLSM in which intravital TPLSM procedures were performed several times over periods of days to months. Red fluorescent protein-expressing colorectal cancer cells were inoculated into the spleens of green fluorescent protein-expressing mice. First- and second-round intravital TPLSM allowed visualization of viable cancer cells (red) in hepatic sinusoids or the space of Disse. Third-round intravital TPLSM demonstrated liver metastatic colonies consisting of viable cancer cells and surrounding stroma with tumor vessels (green). In vivo time-course imaging of tumor angiogenesis in the same living mice using time-series TPLSM could be an ideal tool for antiangiogenic drug evaluation, reducing the effects of interindividual variation. |
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書誌情報 |
Journal of oncology 巻 2012, p. 265487, 発行日 2011-11-03 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1687-8469 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
資源タイプ(三重大) | ||||||
Journal Article / 学術雑誌論文 |